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- BookMalcolm Rowland, Thomas N. Tozer.Summary: This edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response and also reflects the expansion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs.
Contents:
Therapeutic relevance
Fundamental concepts and terminology
Kinetics following an intravenous bolus dose
Membranes and distribution
Elimination
Kinetics following an extravascular dose
Absorption
Response following a single dose
Therapeutic window
Constant-rate input
Multiple-dose regimens
Variability
Genetics
Age, weight, and gender
Disease
Nonlinearities
Drug interactions
Initiating and managing therapy
Distribution kinetics
Metabolites and drug response
Protein drugs
Prediction and refinement of human kinetics from in vitro, preclinical, and early clinical data.